Healing Effects of Rebamipide and Omeprazole in Helicobacter pylori-Positive Gastric Ulcer Patients after Eradication Therapy: A Randomized Double-Blind, Multinational, Multi-Institutional Comparative Study
Digestion, 07/08/2011  Clinical Article

Song KH et al. – Rebamipide is as effective as omeprazole in treating of Helicobacter pylori(H)– positive gastric ulcer after eradication therapy.
Methods

• After completion of 1 week of eradication therapy, 132 patients with H. pylori-positive gastric ulcer were enrolled in 5 Chinese and 4 Korean institutions.
• Patients were randomly assigned to take either 20 mg of omeprazole (n = 63) or 300 mg of rebamipide (n = 65) daily for 7 weeks
• Healing was defined as complete recovery and S1 and S2 stage ulcer according to the Sakita-Miwa classification.

Results

• Healing rates at 12 weeks were 81.5% (53/65) and 82.5% (52/63) in the rebamipide and omeprazole groups, respectively.
• There was no significant difference in treatment efficacy, as evidenced by gastric ulcer healing rates (absolute difference -1.0%; 95% confidence interval -10.7 to 8.7; p = 0.88).
• H. pylori eradication rate and ulcer healing rate did not differ between the groups, the latter regardless of eradication outcome.