| immunoglobulin |
Intravenous immunoglobulin is a blood product, which consists of IgG, although trace quantities of IgA, IgM, dimeric IgG and other plasma proteins are also present. Screening procedures and improved preparation techniques mean that transmission of hepatitis B, hepatitis C, or other detectable blood-borne viruses should not occur.
Adverse effects include tachycardia, chest tightness, headache, lumbar pain, fever and mildly elevated blood pressure. These symptoms usually abate on slowing the infusion rate or after temporary cessation of the infusion. Severe reactions, including Coombs-positive haemolytic anaemia and anaphylaxis, are rare. However, use of intravenous immunoglobulin is contraindicated in patients with selective IgA deficiency because of the risk of anaphylaxis.
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