Approximate equianalgesic doses of various opioids (Table 1.4) [NB1]

Posted by Piscean on


Approximate equianalgesic doses of various opioids (Table 1.4) [NB1]
Opioid Oral Parenteral
morphine
30 mg
10 mg IM/IV/SC [NB2]
codeine oral
180 to 240 mg
–
fentanyl [NB3]
–
100 micrograms IV/IM/SC/epidural
hydromorphone
6 to 7.5 mg
1.5 to 2 mg IM/SC
methadone
[NB4]
[NB4]
oxycodone
15 mg
10 mg IV/SC
pethidine
–
75 to 100 mg IM/SC
tramadol [NB5]
100 to 150 mg
100 mg IM/IV
NB1: These are average equivalent doses because of pharmacokinetic variation between individuals. When changing from one opioid to another, commence with one-third to one-half of the calculated equianalgesic dose and then titrate to response.
NB2: See Table 1.6 for other routes of morphine administration.
NB3: For conversion of morphine to transdermal fentanyl patches, see fentanyl product information.
NB4: Care needs to be taken with methadone to avoid toxicity because the time to reach steady-state concentrations following a change in dosage may be up to 12 days. Dose conversion ratios from other opioids are not static, but are a function of previous opioid exposure, and are highly variable . Consultation with a pain clinic or a palliative care service is advised.
NB5: Tramadol may not be suitable for patients with moderate to severe pain.

Comments

Post a Comment