| Local anaesthetics: mechanism of action |
Local anaesthetics inhibit the generation of electrical impulses and their conduction along the neuronal axon membrane, by reversible block of sodium ion channels. The progression of local anaesthetic block relates to nerve fibre diameter, myelination, and conduction velocity. In general, loss of nerve function occurs in the order of loss of autonomic activity, followed by loss of pain sensation, other sensory functions and finally motor activity.
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