Adjuvants/co-analgesics: antiepileptic drugs
Antiepileptic drugs decrease the excitability of neurones at spinal and brain levels. They work in neuropathic pain by stabilising excitable membranes and preventing repetitive neuronal discharges or by increasing the effectiveness of the major inhibitory network involving gamma-aminobutyric acid (GABA). Antiepileptic drugs have a major place in the treatment of neuropathic pain.
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