How antianginal drugs work
Angina
occurs when the coronary arteries (the heart’s primary source of
oxygen) supply insufficient oxygen to the myocardium. This increases
the heart’s workload, increasing heart rate, preload (blood volume in
the ventricle at the end of diastole), afterload (pressure in the
arteries leading from the ventricle), and force of myocardial
contractility.
Antianginal drugs (nitrates, beta-adreneric blockers, and calcium channel blockers) relieve angina by decreasing one or more of these four factors. This diagram summarizes how antianginal drugs affect the cardiovascular system.
There are three groups of medications that may meet the treatment goals for angina pectoris.1. Nitrates
2. β-Adrenergic Blockers
3. Calcium Channel Blockers
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