| Mechanism of action |
Dextrothyroxine is a antihyperlipidemic. The mechanism of action
is not completely understood, but dextrothyroxine apparently acts in the
liver to stimulate formation of low-density lipoprotein (LDL) and, to a
much greater extent, to increase catabolism of LDL. This leads to
increased excretion of cholesterol and bile acids via the biliary route
into the feces, with a resulting reduction in serum cholesterol and LDL.
Dextrothyroxine has no significant effect on high-density lipoproteins
(HDL).
Inherently, it will also bind to thyroid receptors and as it is a
prohormone, it will bind as a substrate to iodide peroxidase. |
