Pharmacology Of Ceftibuten

Indication	Used to treat acute bacterial exacerbations of chronic bronchitis (ABECB), acute bacterial otitis media, pharyngitis, and tonsilitis.
Pharmacodynamics	Ceftibuten is a third-generation cephalosporin antibiotic.
Mechanism of action	Ceftibuten exerts its bactericidal action by binding to essential target proteins of the bacterial cell wall. This binding leads to inhibition of cell-wall synthesis.
Absorption	Rapidly absorbed following oral administration.
Volume of distribution	0.21 L/kg [adult subjects] 0.5 L/kg [fasting pediatric patients]
Protein binding	Ceftibuten is 65% bound to plasma proteins. The protein binding is independent of plasma ceftibuten concentration.
Metabolism	A study with radiolabeled ceftibuten administered to 6 healthy adult male volunteers demonstrated that cis-ceftibuten is the predominant component in both plasma and urine. About 10% of ceftibuten is converted to the trans-isomer is approximately 1/8 as antimicrobially potent as the cis-isomer.
Route of elimination	Ceftibuten is excreted in the urine; 95% of the administered radioactivity was recovered either in urine or feces.
Half life	Not Available
Clearance	Not Available
Toxicity	Overdosage of cephalosporins can cause cerebral irritation leading to convulsions