| Indication | Used, along with rest and physical therapy, to treat injuries and other painful muscular conditions. Investigated for use in trigeminal neuralgia (tic douloureux), a neuropathic disorder characterized by severe facial pain. Was investigated as a modulator of histamine release. |
| Pharmacodynamics | Chlorphenesin is a muscle relaxant. It blocks nerve impulses (or pain sensations) that are sent to the brain. |
| Mechanism of action | The mechanism of action of chlorphenesin is not well defined, and its effects are measured mainly by subjective responses. It is known that chlorphenesin acts in the central nervous system (CNS) rather than directly on skeletal muscle. |
| Absorption | Rapid and complete. |
| Volume of distribution | Not Available |
| Protein binding | Not Available |
| Metabolism | Hepatic. 85% of a dose excreted within 24 hours as the glucuronide metabolite. |
| Route of elimination | Not Available |
| Half life | 2.3-5 hours |
| Clearance | Not Available |
| Toxicity | Symptoms of a chlorphenesin overdose include drowsiness and nausea. |