Indication |
Topical antiseptic used mainly in wound dressings. |
Pharmacodynamics |
Proflavine is an acriflavine derivative which is a disinfectant
bacteriostatic against many gram-positive bacteria. Proflavine is toxic
and carcinogenic in mammals and so it is used only as a surface
disinfectant or for treating superficial wounds. |
Mechanism of action |
Proflavine acts by interchelating DNA (intercalation), thereby
disrupting DNA synthesis and leading to high levels of mutation in the
copied DNA strands. This prevents bacterial reproduction. |
Absorption |
Not Available |
Volume of distribution |
Not Available |
Protein binding |
Not Available |
Metabolism |
Not Available |
Route of elimination |
Not Available |
Half life |
Not Available |
Clearance |
Not Available |
Toxicity |
Not Available |
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