RISK STRATIFICATION OF ANGINA


Table  -- Likelihood of Ischemic Etiology and Short-Term Risk
Part I. Chest Pain Patients Without ST-Segment Elevation: Likelihood of Ischemic Etiology
A. High Likelihood B. Intermediate Likelihood C. Low Likelihood

High likelihood that chest pain is of ischemic etiology if patient has any of the findings in the column below: Intermediate likelihood that chest pain is of ischemic etiology if patient has NO findings in column A and any of the findings in the column below: Low likelihood that chest pain is of ischemic etiology if patient has NO findings in column A or B. Patients may have any of the findings in the column below:
History

Chief symptom is chest or left arm pain or discomfort plus

Current pain reproduces pain of previous documented angina and known CAD, including MI

Chief symptom is chest or left arm pain or discomfort

Age >70 years

Male sex

Diabetes mellitus

Probably ischemic symptoms

Recent cocaine use
Physical exam

Transient mitral regurgitation

Hypotension

Diaphoresis

Pulmonary edema or rales
Extracardiac vascular disease Chest discomfort reproduced by palpation
ECG New (or presumed new) transient ST deviation (≥0.5 mm) or T-wave inversion (≥2 mm) with symptoms

Fixed Q waves

Abnormal ST segments or T waves that are not new

Normal ECG or

T-wave flattening or

T-wave inversion in leads with dominant R waves

Normal cardiac markers
Cardiac markers

Elevated troponin I or T

Elevated CK-MB

Any finding in column B above

PLUS

Normal cardiac markers
Part II. Risk of Death or Nonfatal MI Over the Short Term in Patients With Chest Pain With High or Intermediate Likelihood of Ischemia (Columns A and B in Part I)
High Risk Intermediate Risk Low Risk
Risk is high if patient has any of the following findings: Risk is intermediate if patient has any of the following findings: Risk is low if patient has NO high- or intermediate-risk features; may have any of the following:
History Accelerating tempo of ischemic symptoms over previous 48 hours

Prior MI or

Peripheral-artery disease or

Cerebrovascular disease or

CABG, previous aspirin use
Character of Pain Prolonged, continuing (>20 min) rest pain

Prolonged (>20min) rest angina is now resolved (moderate to high likelihood of CAD)

Rest angina (<20min by="by" nitrates="nitrates" or="or" relieved="relieved" rest="rest" span="span" sublingual="sublingual">
New-onset functional angina (Class III or IV) in past 2 weeks without prolonged rest pain (but with moderate or high likelihood of CAD)
Physical exam

Pulmonary edema secondary to ischemia

New or worse mitral regurgitation murmur

Hypotension, bradycardia, tachycardia

S3 gallop or new or worsening rales

Age >75 years
Age >70 years
ECG

Transient ST deviation (≥0.5 mm) with rest angina

New or presumably new bundle branch block

Sustained VT

T-wave inversion ≥2 mm

Pathologic Q waves or T waves that are not new
Normal or unchanged ECG during an episode of chest discomfort
Cardiac markers Elevated cardiac troponin I or T Any of the above findings PLUS Normal cardiac markers
Elevated CK-MB Normal cardiac markers
From 2005 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care, Part 8: Stabilization of the Patient With Acute Coronary Syndromes. Circulation 112 (suppl IV) 2005.
High (A) or Intermediate (B)
Likelihood of Ischemia