| Indication | For relief of acute bronchial asthma and for reversible bronchospasm associated with chronic bronchitis and emphysema. |
| Pharmacodynamics | Dyphylline, a xanthine derivative, is a bronchodilator used for relief of acute bronchial asthma and for reversible bronchospasm associated with chronic bronchitis and emphysema. Dyphylline is a xanthine derivative with pharmacologic actions similar to theophylline and other members of this class of drugs. Its primary action is that of bronchodilation, but it also exhibits peripheral vasodilatory and other smooth muscle relaxant activity to a lesser degree. |
| Mechanism of action | The bronchodilatory action of dyphylline, as with other xanthines, is thought to be mediated through competitive inhibition of phosphodiesterase with a resulting increase in cyclic AMP producing relaxation of bronchial smooth muscle as well as antagonism of adenosine receptors. |
| Absorption | Not Available |
| Volume of distribution | Not Available |
| Protein binding | 84% |
| Metabolism | Hepatic |
| Route of elimination | Dyphylline exerts its bronchodilatory effects directly and, unlike theophylline, is excreted unchanged by the kidneys without being metabolized by the liver. Approximately 88% of a single oral dose can be recovered from the urine unchanged. |
| Half life | 2 hours (range 1.8 - 2.1 hours) |
| Clearance | Not Available |
| Toxicity | LD50=1954 mg/kg (orally in mice) |
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