Pharmacology Of Fluorescein

Indication	For diagnostic imaging. Primarily indicated in diagnostic fluorescein angiography or angioscopy of the fundus and of the iris vasculature.
Pharmacodynamics	Not Available
Mechanism of action	Fluorescein sodium is used extensively as a diagnostic tool in the field of ophthalmology. Fluorescein is a fluorescent compound or fluorophore having a maximum absorbance of 494 m and an emission maximum of 521 nm. The yellowish-green fluorescence of the compound can be used to demarcate the vascular area under observation, distinguishing it from adjacent areas. It is applied topically in the form of a drop or it can be injected intravenously to produce a fluorescein angiogram. Topical fluorescein is a useful tool in the diagnosis of corneal abrasions, corneal ulcers, herpetic corneal infections, and dry eye. Fluorescein angiography is used to diagnose and categorize macular degeneration, diabetic retinopathy, inflammatory intraocular conditions, and intraocular tumors.
Absorption	Rapidly distributed
Volume of distribution	0.5 L/kg
Protein binding	85%
Metabolism	Not Available
Route of elimination	Fluorescein and its metabolites are mainly eliminated via renal excretion.
Half life	Not Available
Clearance	renal cl=1.75 mL/min/kg [After IV administration] hepatic cl=1.50 mL/min/kg [After IV administration]
Toxicity	Not Available