| Indication | For treatment of Severe malaria |
| Pharmacodynamics | Halofantrine is a synthetic antimalarial which acts as a blood schizonticide. It is effective against multi drug resistant (including mefloquine resistant) P. falciparum malaria. |
| Mechanism of action | The mechanism of action of Halofantrine may be similar to that of chloroquine, quinine, and mefloquine; by forming toxic complexes with ferritoporphyrin IX that damage the membrane of the parasite. |
| Absorption | Not Available |
| Volume of distribution | Not Available |
| Protein binding | 60-70%; |
| Metabolism | Hepatic |
| Route of elimination | Not Available |
| Half life | 6-10 days |
| Clearance | Not Available |
| Toxicity | Side effects incldue coughing noisy, rattling, troubled breathing, loss of appetite, aches and pain in joints, indigestion,and skin itching or rash. |
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