| Indication | For treatment of Schistosomiasis caused by Schistosoma mansoni |
| Pharmacodynamics | Oxamniquine is an anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release egg. |
| Mechanism of action | Oxamniquine may associate with an irreversible inhibition of the nucleic acid metabolism of the parasites. A hypothesis has been put forth that the drug is activated by a single step, in which a schistosome sulfotransferase enzyme converts oxamniquine into an ester (probably acetate, phosphate, or sulfate). Subsequently, the ester spontaneously dissociates, the resulting electrophilic reactant is capable of alkylation of schistosome DNA. |
| Absorption | Well absorbed orally |
| Volume of distribution | Not Available |
| Protein binding | Not Available |
| Metabolism | Probably hepatic |
| Route of elimination | Not Available |
| Half life | 1-2.5 hours |
| Clearance | Not Available |
| Toxicity | Not Available |
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