| Indication | Used as a diagnostic aid for evaluation of gastric acid secretory function |
| Pharmacodynamics | Pentagastrin is indicated as a diagnostic aid for evaluation of gastric acid secretory function. It is effective in testing for anacidity (achlorhydria) in patients with suspected pernicious anemia, atrophic gastritis, or gastric carcinoma. It is also effective in determining the reduction in acid output after operations for peptic ulcer, such as vagotomy or gastric resection. |
| Mechanism of action | The exact mechanism by which pentagastrin stimulates gastric acid, pepsin, and intrinsic factor secretion is unknown; however, since pentagastrin is an analogue of natural gastrin, it is believed that it excites the oxyntic cells of the stomach to secrete to their maximum capacity. Pentagastrin stimulates pancreatic secretion, especially when administered in large intramuscular doses. Pentagastrin also increases gastrointestinal motility by a direct effect on the intestinal smooth muscle. However, it delays gastric emptying time probably by stimulation of terminal antral contractions, which enhance retropulsion. |
| Absorption | Rapidly absorbed after parenteral administration. |
| Volume of distribution | Not Available |
| Protein binding | Not Available |
| Metabolism | Primarily hepatic |
| Route of elimination | Not Available |
| Half life | 10 minutes or less |
| Clearance | Not Available |
| Toxicity | Not Available |
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